Role for beta-catenin and HOX transcription factors in Caenorhabditis elegans and mammalian host epithelial-pathogen interactions.
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Category: Immunology  

By J. Irazoqui
5 months ago

ABSTRACT
We used the model nematode Caenorhabditis elegans infected with the human pathogen Staphylococcus aureus to identify components of epithelial immunity. Transcriptional profiling and reverse genetic analysis revealed that mutation of the C. elegans beta-catenin homolog bar-1 or the downstream homeobox gene egl-5 results in a defective response and hypersensitivity to S. aureus infection. Epistasis analysis showed that bar-1 and egl-5 function in parallel to previously described C. elegans immune-response pathways. Overexpression of human homologs of egl-5 modulated NF-kappaB-dependent TLR2 signaling in epithelial cells. These data suggest that beta-catenin and homeobox genes play an important and conserved role in innate immune defense.
Source
Proceedings of the National Academy of Sciences of (2008)

Irazoqui JE, Ng A, Xavier RJ, Ausubel FM,
PMID 18981407
Keywords
catenin | transcription | factors | Caenorhabditis | elegans | mammalian | epithelial | pathogen | interactions
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